We create transparency and accountability for multiple healthcare donor programs in Africa. M-TIBA uses secure cloud-based servers and mobile phone technology to digitally connect donors, providers, and patients. This is revolutionizing the management of large-scale health schemes and health information systems, needed to support universal health coverage in Africa. Clinical transaction data is available in real-time, including ICD10-coded symptoms, diagnoses, and prescriptions. This is helping donors and policy-makers target their responses to COVID-19, maternal health, malaria, and a range of other treatment areas.